DNA vaccination is a promising new approach for the prevention and treatment of many diseases because of its ability to induce both humoral and cellular immune responses against antigens encoded by recombinant DNA. This strategy has been used successfully for infectious diseases and potentially can be applied for malignant conditions.
Although DNA vaccines have a number of disadvantages such as Risk of affecting genes controlling cell growth they also have a several of advantages over conventional vaccines which one of the most important is the ability to induce a wide range of immune response types. In fact several approaches have been investigated to improve DNA vaccines including plasmid design delivery techniques ect. The goals of the various clinical trials were to demonstrate the safety and tolerability of the candidate vaccines and to explore the efficacy of DNA vaccines in humans.
This presentation focuses on how DNA vaccines work as well as the mechanisms by which DNA vaccination induces immune responses and some representative DNA cancer vaccine studies ( at phases 1&2) .An overview of the human clinical trials is also presented.
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